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Administrative Development Drug User Resources Nutrition and Metabolism Epidemiology and Biostatistics Hepatitis and Liver Function

Core:
Nutrition & Metabolism

Core Leader:
Christine Wanke, MD
Tufts University School of Medicine

Core Overview:
The Nutrition and Metabolism Core provides expert advice and resources on issues related to the nutritional and metabolic consequences of drug users with and without HIV infection. Services include consultations and training and/or written protocols on appropriate nutrition, metabolic, and/or quality of life measures. This Core also includes expert advice on the effects of drug use on glucose metabolism and the endocrine system (previously the Endocrine Core).

Core Services:

Consultation Services:

  • Protocol development using appropriate nutritional and metabolic measures. This includes study design, populations considerations, frequency of follow-up measures, etc.
  • Inclusion of clinical nutrition assessment parameters appropriate to the study design and population, including wasting, obesity, fat redistribution, vitamin deficiencies, and energy expenditure.
  • Inclusion of immune function and metabolic assessment parameters appropriate to the study design and population, including glucose and insulin levels, lipid analyses (total cholesterol, triglycerides, LDL-C, HDL-C, Lipoprotein-A), and C-reactive protein assessment.

On-Site Training:

  • Body Composition Measurements
    • Anthropometry
    • Bioelectrical Impedence (BIA)
    • Dual X-ray Absorptiometry (DEXA)
    • CT scans of abdomen and thigh
  • Dietary Intake
    • 24-hour recall instrument, specific to drug-using populations
    • Nutrient analyses of dietary data
  • Physical Activity
    • Physical activity/caloric expenditure assessment methods
  • Quality of Life
    • Data collection instruments to assess quality of life issues

Forms/Materials:

  • Resting Energy Expenditure Protocol
  • Anthropometry Protocol
  • Bioelectrical Impedence (BIA) Protocol
  • Dual X-ray Absorptiometry (DEXA) Protocol
  • CT Scans (abdomen and thigh) Protocol
  • Dietary Assessment Protocols
  • Physical Activity Assessment Protocols
  • Quality of Life Instruments

Serum Assays:

  • There will be a small charge for supplies (test kits) related to the following assays:
  • Micronutrients: vitamin A, E, carotenoids, selenium, and zinc and measures of oxidative stress
  • Antiretroviral Drug Levels: nucleosides, non-nucleosides, protease inhibitors
  • Cytokine
  • Leptin
  • Adiponectin
  • Glucose and Insulin
  • Oral Glucose Tolerance Test

Specimen Archiving

  • Specimens can be archived and monitored for future analysis with our sophisticated freezer database system.

If you are interested in learning more about this Core’s services, please contact Kim at .

 

 

 

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